Invitrogen™ Androgen Receptor Monoclonal Antibody (H7507)

Catalog No.	Quantity
41-590-0	100 μL

Catalog No. 41-590-0 Supplier Invitrogen™ Supplier No. 415900

Description

Mouse Monoclonal Antibody

This antibody specifically recognizes human AR and cross reacts with mouse and rat AR.

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis.AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

Specifications

• Antigen: Androgen Receptor
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: H7507
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: Physiological saline with 0.1% sodium azide
• Gene: AR
• Gene Accession No.: P10275, P15207, P19091
• Gene Alias: AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
• Gene Symbols: AR
• Host Species: Mouse
• Immunogen: Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human AR (2-53 aa).
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11835, 24208, 367
• Target Species: Human, Mouse, Rat
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 1 month. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a