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Tocris Bioscience™ Angiopep-2
SDP

Catalog No. 88281 Shop All R&D Systems Products
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88-281 1 mg
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Catalog No. 88-281 Supplier Tocris Bioscience™ Supplier No. 8828/1
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Description

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Angiopep-2 is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present both on blood-brain barrier (BBB) and tumor cell membranes. Angiopep-2 binding to LRP1 facilitates receptor-mediated transcytosis of cargo across the BBB. Transcytosis-inducing molecular degraders of extracellular proteins (TransMoDEs), containing Angiopep-2 and modified to include a small-molecule ligand, induce target internalization that can cross the BBB in a variety of cell types.

Specifications

CAS 906480-05-5
Quantity 1 mg
Target LDL Receptor Peptides
Molecular Formula C104H149N29O31
Product Type Bioactive Small Molecule
Purity ≥95% (HPLC)
Molecular Weight (g/mol) 2301.5
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