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Invitrogen™ Angiopoietin 2 Monoclonal Antibody (07), Invitrogen™

Catalog No. PIMA543395
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PIMA543395 50 μL
PIMA542997 100 μL
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Catalog No. PIMA543395 Supplier Invitrogen™ Supplier No. MA543395
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Description

Mouse Monoclonal Antibody

Specificity: Human Angiopoietin-2

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 2
Applications ELISA
Classification Monoclonal
Clone 07
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ANGPT2
Gene Accession No. O15123
Gene Alias AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Gene Symbols ANGPT2
Host Species Mouse
Immunogen Recombinant Human Angiopoietin-2 Protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 285
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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