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Invitrogen™ Angiopoietin 2 Polyclonal Antibody
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Catalog No. PIPA129640
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100 μL
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PIPA129640 100 μL
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Catalog No. PIPA129640 Supplier Invitrogen™ Supplier No. PA129640
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Description

Rabbit Polyclonal Antibody

This antibody is specific for mouse Angiopoietin-2 (mAng-2). Partial cross-reactivity is observed with human Angiopoietin-1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 80 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.2
Gene ANGPT2
Gene Accession No. O15123, O35608
Gene Alias AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Gene Symbols ANGPT2
Host Species Rabbit
Immunogen Synthetic peptide, corresponding to a region near the N-terminus of mouse angiopoietin-2 protein, conjugated to KLH using maleimide.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11601, 285
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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