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Invitrogen™ Angiopoietin 2 Polyclonal Antibody
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Catalog No. 407600
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Catalog No. Quantity
40-760-0 100 μg
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Catalog No. 40-760-0 Supplier Invitrogen™ Supplier No. 407600
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Description

Rabbit Polyclonal Antibody

Angiopoietin 2 Polyclonal Antibody for Western Blot

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis. The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels. Mature human ANG-2 is a secreted protein containing 480 amino acid residues. ANG-2 is composed of an alpha-helix-rich coiled coil N-terminal domain and fibrinogen-like C-terminal domain. ANG-2 exists predominantly in the form of a disulfide-linked dimer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 2
Applications Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene ANGPT2
Gene Accession No. O15123
Gene Alias AGPT2; Ang2; Ang-2; angiopoietin 2; angiopoietin-2; angiopoietin-2a; angiopoietin-2B; ANGPT2; endothelial growth factor; Tie2-ligand
Gene Symbols ANGPT2
Host Species Rabbit
Immunogen Synthetic peptide derived from the N-terminal region of the human, gorilla, and orangutan angiogenin protein, which differs from mouse by one amino acid.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 285
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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