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Invitrogen™ Angiopoietin 3 Polyclonal Antibody
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Catalog No. PIPA547921
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100 μg
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PIPA547921 100 μg
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Catalog No. PIPA547921 Supplier Invitrogen™ Supplier No. PA547921
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Description

Goat Polyclonal Antibody

In Western blots, no cross-reactivity with recombinant human (rh) Angiopoietin-2 or rhAngoipoietin-3 was observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a cell surface receptor tyrosine kinase expressed in endothelial and hemopoietic cells. Ang-1 is an angiogenic factor that mediates blood vessel maturation and may be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), is a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression is restricted to sites of vascular remodeling. Ang-3 and Ang-4 represent the mouse and human counterparts of the same gene locus. The structural divergence of Ang-3 and Ang-4 cause their divergent functions. Ang-3 and Ang-4 have very different distributions in their respective species, and Ang-3 appears to act as an antagonist while Ang-4 appears to function as an agonist. Ang-3 and Ang-4 share all the main structural characteristics of Ang-1 and Ang-2 and are homologous throughout the signal peptide, N-terminal region, coiled-coil segment and Fibrinogen-like domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 3
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene ANGPT4
Gene Accession No. Q9WVH6
Gene Alias AGP4; Agpt4; ANG3; ANG-3; ANG4; ANG-4; angiopoietin 3; angiopoietin 4; Angiopoietin3; angiopoietin-3; Angiopoietin4; Angiopoietin-4; Angpt4
Gene Symbols ANGPT4
Host Species Goat
Immunogen E. coli-derived recombinant mouse Angiopoietin-3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11602
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

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