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Invitrogen™ Angiopoietin 4 Polyclonal Antibody
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Catalog No. PIPA534780
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PIPA534780 100 μL
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Catalog No. PIPA534780 Supplier Invitrogen™ Supplier No. PA534780
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji. IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a cell surface receptor tyrosine kinase expressed in endothelial and hemopoietic cells. Ang-1 is an angiogenic factor that mediates blood vessel maturation and may be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), is a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression is restricted to sites of vascular remodeling. Ang-3 and Ang-4 represent the mouse and human counterparts of the same gene locus. The structural divergence of Ang-3 and Ang-4 cause their divergent functions. Ang-3 and Ang-4 have very different distributions in their respective species, and Ang-3 appears to act as an antagonist while Ang-4 appears to function as an agonist. Ang-3 and Ang-4 share all the main structural characteristics of Ang-1 and Ang-2 and are homologous throughout the signal peptide, N-terminal region, coiled-coil segment and Fibrinogen-like domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 4
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene ANGPT4
Gene Accession No. Q9Y264
Gene Alias AGP4; Agpt4; ANG3; ANG-3; ANG4; ANG-4; angiopoietin 3; angiopoietin 4; Angiopoietin3; angiopoietin-3; Angiopoietin4; Angiopoietin-4; Angpt4
Gene Symbols ANGPT4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Angiopoietin 4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51378
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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