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Invitrogen™ Angiopoietin 4 Polyclonal Antibody
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Catalog No. PIPA5103604
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PIPA5103604 100 μL
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Catalog No. PIPA5103604 Supplier Invitrogen™ Supplier No. PA5103604
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ANGPT4.

Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a cell surface receptor tyrosine kinase expressed in endothelial and hemopoietic cells. Ang-1 is an angiogenic factor that mediates blood vessel maturation and may be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), is a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression is restricted to sites of vascular remodeling. Ang-3 and Ang-4 represent the mouse and human counterparts of the same gene locus. The structural divergence of Ang-3 and Ang-4 cause their divergent functions. Ang-3 and Ang-4 have very different distributions in their respective species, and Ang-3 appears to act as an antagonist while Ang-4 appears to function as an agonist. Ang-3 and Ang-4 share all the main structural characteristics of Ang-1 and Ang-2 and are homologous throughout the signal peptide, N-terminal region, coiled-coil segment and Fibrinogen-like domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiopoietin 4
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ANGPT4
Gene Accession No. Q9WVH6, Q9Y264
Gene Alias AGP4; Agpt4; ANG3; ANG-3; ANG4; ANG-4; angiopoietin 3; angiopoietin 4; Angiopoietin3; angiopoietin-3; Angiopoietin4; Angiopoietin-4; Angpt4
Gene Symbols ANGPT4
Host Species Rabbit
Immunogen A synthesized peptide derived from human ANGPT4(Accession Q9Y264), corresponding to amino acid residues G327-S377.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11602, 51378
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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