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Invitrogen™ Angiotensinogen Polyclonal Antibody
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Catalog No. PIPA590591
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100 μL
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PIPA590591 100 μL
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Catalog No. PIPA590591 Supplier Invitrogen™ Supplier No. PA590591
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Description

Rabbit Polyclonal Antibody

Positive Samples: HepG2 Immunogen sequence: RVYIHPFHLV IHNESTCEQL AKANAGKPKD PTFIPAPIQA KTSPVDEKAL QDQLVLVAAK LDTEDKLRAA MVGMLANFLG FRIYGMHSEL WGVVHGATVL SPTAVFGTLA SLYLGALDHT ADRLQAILGV PWKDKNCTSR LDAHKVLSAL QAVQGLLVAQ GRADSQAQLL LSTVVGVFTA PGLHLKQPFV QGLALYTPVV LPRSLDFTEL DVAAEKIDRF MQAVTGWKTG CSLMGASVDS TLAFNTYVHF QGKMKGFSLL AEPQEFWVDN STSVSVPMLS GMGTFQHWSD IQDNFSVTQV PFTESACLLL IQPHYASDLD KVEGLTFQQN SLNWMKKLSP RTIHLTMPQL VLQGSYDLQD LLAQAELPAI LHTELNLQKL SNDRIRVGEV LNSIFFELEA DEREPTESTQ QLNKPEVLEV TLNRPFLFAV YDQSATALHF LGRVANPLST A.

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Angiotensinogen
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene AGT
Gene Accession No. P01015, P01019, P11859
Gene Alias AGT; AI265500; alpha-1 antiproteinase, antitrypsin; Ang; Ang I; Ang II; Ang III; Ang IV; AngI; AngII; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; angiotensin ll; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; ANRT; Aogen; Des-Asp[1]-angiotensin II; PAT; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; Serpina8
Gene Symbols AGT
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 35-485 of human Angiotensinogen (NP_0000201).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11606, 183, 24179
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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