Invitrogen™ Angiotensinogen Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547888

Catalog No. PIPA547888

Description

In direct ELISAs, approximately 24% cross-reactivity with recombinant human Angiotensinogen is observed, and less than 1% cross-reactivity with recombinant mouse (rm) Serpin A1, rmSerpin C1, and rmSerpin F2 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Specifications

• Antigen: Angiotensinogen
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AGT
• Gene Alias: AGT; AI265500; alpha-1 antiproteinase, antitrypsin; Ang; Ang I; Ang II; Ang III; Ang IV; AngI; AngII; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; angiotensin ll; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; ANRT; Aogen; Des-Asp[1]-angiotensin II; PAT; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; Serpina8
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11606, 24179
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P01015, P11859
• Gene Symbols: AGT
• Immunogen: CHO-derived recombinant mouse Serpin A8/Angiotensinogen Asp25-Val477.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG