Invitrogen™ Angiotensinogen Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578741

Catalog No. PIPA578741

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: mouse liver tissue, mouse liver tissue. IHC: mouse liver tissue.

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Specifications

• Antigen: Angiotensinogen
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AGT
• Gene Alias: AGT; AI265500; alpha-1 antiproteinase, antitrypsin; Ang; Ang I; Ang II; Ang III; Ang IV; AngI; AngII; Angiotensin 1-10; Angiotensin 1-4; Angiotensin 1-5; Angiotensin 1-7; Angiotensin 1-8; Angiotensin 1-9; Angiotensin 2-8; Angiotensin 3-8; Angiotensin I; angiotensin II; Angiotensin III; Angiotensin IV; angiotensin ll; Angiotensin-1; Angiotensin-2; Angiotensin-3; Angiotensin-4; Angiotensinogen; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; ANRT; Aogen; Des-Asp[1]-angiotensin II; PAT; pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; serpin A8; serpin peptidase inhibitor, clade A, member 8; Serpina8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11606
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P11859
• Gene Symbols: AGT
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Angiotensinogen (25-36aa DRVYIHPFHLLY).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG