Invitrogen™ ANK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114853

Catalog No. PIPA5114853

Description

Antibody detects endogenous levels of total Ankyrin erythroid.

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

Specifications

• Antigen: ANK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANK1
• Gene Alias: ANK; ANK1; ANK-1; ANK-1; erythrocyte skeletal protein; ankyrin 1; ankyrin 1, erythrocytic; ankyrin 1, erythroid; ankyrin-1; Ankyrin-R; erythrocyte ankyrin; nb; normoblastic anemia; pale; rCG_43073; SPH1; SPH2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11733, 286, 306570
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P16157, Q02357
• Gene Symbols: ANK1
• Immunogen: A synthesized peptide derived from human ANK1(Accession P16157), corresponding to amino acid residues V1134-Q1184.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG