Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ ANKRD1/CARP, Mouse, Unlabeled, Clone: 12G8.2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABS1228

Catalog No. MABS1228MI


Only null left
Add to Cart

Description

Description

Ankyrin repeat domain-containing protein 1 (UniProt Q15327; also known as Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein) is encoded by the ANKRD1 (also known as C193, CARP, HA1A2) gene (Gene ID 27063) in human. ANKRD1/CARP belongs to a family of conserved muscle ankyrin repeat proteins (MARPs), members of which also include ANKRD2 and diabetes ankyrin repeat protein (DARP, ANKRD23). ANKRD1 is highly expressed in cardiomyocytes and known to interact with myopalladin and titin, implicating its roles in myopalladin complex-dependent sarcomere integrity maintenance and stress-induced gene regulations medidated by the titin complex. ANKRD1 is up-regulated in patients with dilated cardiomyopathy and in animal models of cardiac hypertrophy induced by pressure overload and adrenergic stimulation. ANKRD1 is shown to regulate the hypertrophic agonist phenylephrine-/PE-induced α-adrenergic signaling pathway in neonatal rat ventricular myocytes, where it recruits and localizes ERK1/2 and GATA4 in a sarcomeric complex, resulting in enhanced GATA4 phosphorylation and subsequent ANKRD1 complex nuclear translocation and gene activation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ANKRD1/CARP
Monoclonal
Please refer to lot specific datasheet.
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Q15327
GST-tagged recombinant human ANKRD1/CARP fragment corresponding ankyrin repeats 4&5.
100 μg
Signaling
NP_055206
Stable for 1 year at 2°-8°C from date of receipt.
IgG1 κ
Western Blot
12G8.2
Unconjugated
ANKRD1, C193, CARP, HA1A2
Mouse
Protein G Purified
RUO
Primary
Human
Purified
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.

For Research Use Only. Not for use in diagnostic procedures.