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Invitrogen™ ANKRD27 Polyclonal Antibody
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Catalog No. PIPA5106948
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100 μL
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PIPA5106948 100 μL
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Catalog No. PIPA5106948 Supplier Invitrogen™ Supplier No. PA5106948
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 77%; Dog: 93%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Mouse: 91%; Rabbit: 93%.

May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen ANKRD27
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene ANKRD27
Gene Accession No. Q96NW4
Gene Alias ANKRD27; ankyrin repeat domain 27; ankyrin repeat domain 27 (VPS9 domain); ankyrin repeat domain-containing protein 27; PP12899; VARP; Vps9 domain and ankyrin-repeat-containing protein; VPS9 domain-containing protein; VPS9-ankyrin-repeat protein
Gene Symbols ANKRD27
Host Species Rabbit
Immunogen Synthetic peptide directed towards the C-terminal region of human ANKRD27.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84079
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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