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ANKRD28/PITK Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501558929
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50-155-8929 20 μL
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Catalog No. 50-155-8929 Supplier Bethyl Laboratories, Inc Supplier No. A300974AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. ANKRD28 selectively regulated phosphorylation of hnRNP-K at ser284, an effect that was enhanced in vivo by an S1013A/S1017A double mutant, suggesting that ANKRD28 targets PP1 in a regulated manner to dephosphorylate hnRNP-K selectively at ser284.

Specifications

Antigen ANKRD28/PITK
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene ANKRD28
Gene Accession No. O15084
Gene Alias KIAA0379
Gene Symbols ANKRD28
Host Species Rabbit
Immunogen Between 975 and 1025
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23243
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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