Invitrogen™ Ankyrin 1 Polyclonal Antibody

Catalog No.	Quantity
PIPA552121	100 μL

Catalog No. PIPA552121 Supplier Invitrogen™ Supplier No. PA552121

Description

Rabbit Polyclonal Antibody

Immunogen sequence: QNVMHIVRGS LCFVLKHIHQ ELDKELGESE GLSDDEETIS TRVVRRRVFL KGNEFQNIPG EQVTEEQFTD EQGNIVTKKI IRKVVRQIDL SSADAAQEHE EVELRGSGLQ PDLIEGRKGA QIVKRASLK Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 53%.

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

Specifications

• Antigen: Ankyrin 1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ANK1
• Gene Accession No.: P16157
• Gene Alias: ANK; ANK1; ANK-1; ANK-1; erythrocyte skeletal protein; ankyrin 1; ankyrin 1, erythrocytic; ankyrin 1, erythroid; ankyrin-1; Ankyrin-R; erythrocyte ankyrin; nb; normoblastic anemia; pale; rCG_43073; SPH1; SPH2
• Gene Symbols: ANK1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human Ankyrin 1. Recombinant protein control fragment (Product #RP-102463).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 286
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG