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Invitrogen™ Ankyrin B Monoclonal Antibody (N105/13), FITC
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Catalog No. PIMA545527
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100 μg
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Catalog No. Quantity
PIMA545527 100 μg
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Catalog No. PIMA545527 Supplier Invitrogen™ Supplier No. MA545527
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45527 was sufficient for detection of Ankyrin-B in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 200kDa. No cross reactivity against Ankyrin-G. This antibody was formerly sold as clone S105-13.

This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ankyrin B
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N105/13
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gene ANK2
Gene Accession No. Q01484, Q8C8R3
Gene Alias AI835472; Ank2; ANK-2; Ank3; AnkB; ankyrin 2, brain; ankyrin 2, neuronal; ankyrin 3, epithelial; ankyrin B; ankyrin, brain; ankyrin-2; ankyrin-2, nonerythrocytic; ankyrin-B; AW491075; Brain ankyrin; brank-2; LQT4; Non-erythroid ankyrin
Gene Symbols ANK2
Host Species Mouse
Immunogen Synthetic peptide amino acids 203-496 of human Ankyrin-B.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109676, 287, 362036
Target Species Human, Mouse, Rat
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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