Invitrogen™ Annexin A6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527462

Catalog No. PIPA527462

Description

Recommended positive controls: H1299, NIH-3T3. Predicted reactivity: Mouse (95%), Rat (95%), Chicken (80%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.

Specifications

• Antigen: Annexin A6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANXA6
• Gene Alias: 67 kDa calelectrin; Annexin A6; annexin VI; annexin VI (p68); annexin VI, p68; annexin-6; Anx6; ANXA6; AnxVI; AW107198; Cabm; calcium-binding protein 65/67; calcium-binding protein CATA 65/67; calcium-binding protein p68; calelectrin; calphobindin II; calphobindin-II; Camb; CBP 65/67; CBP68; chromobindin-20; CPB-II; lipocortin VI; p68; p70; Protein III; testis secretory sperm-binding protein Li 198a
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11749, 309
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.179 mg/mL
• Formulation: PBS with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P08133, P14824
• Gene Symbols: ANXA6
• Immunogen: Recombinant fragment corresponding to a region within amino acids 475 and 673 of Human Annexin VI.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG