Annexin V Mouse anti-Human, FITC, Clone: VAA-33, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NB141847	Novus Biologicals NB1006330750TESTS	50 Tests

Description

Annexin V Monoclonal specifically detects Annexin V in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: Annexin V
• Concentration: 0.2mg/mL
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Mouse
• Research Discipline: Apoptosis
• Gene Accession No.: P08758
• Gene ID (Entrez): 308
• Immunogen: Recombinant Annexin V
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

• Clone: VAA-33
• Dilution: Flow Cytometry 1:10-1:1000
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: Anchorin CII, annexin A5, Annexin V, annexin-5, ANX5, Calphobindin I, Endonexin II, ENX2CBP-I, Lipocortin V, PAP-I, Placental anticoagulant protein 4, Placental anticoagulant protein I, PP4, Thromboplastin inhibitor, VAC-alpha, Vascular anticoagulant-alpha
• Gene Symbols: ANXA5
• Isotype: IgG2a
• Purification Method: Protein G purified
• Test Specificity: NB100-64303 specifically recognizes human Annexin V, a phospholipid binding protein which binds with high affinity and selectivity to phosphatidylserine (PS), in the presence of calcium. The translocation of PS from the cytosolic leaflet to the outer leaflet of the plasma membrane, due to a loss in plasma membrane asymmetry during apoptosis, acts as an in vivo signal for the removal of the dying cell by phagocytosis. Detection of PS using Annexin V therefore provides a reliable diagnostic tool for the indication of early programmed cell death. Annexin V has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin V, are associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc). Clone VAA-33 has been reported to work in western blotting applications.

For Research Use Only