Invitrogen™ Anthrax Lethal Factor Polyclonal Antibody

Catalog No.	Quantity
01-675-744	200 μL

Catalog No. 01-675-744 Supplier Invitrogen™ Supplier No. PA141171

Description

Rabbit Polyclonal Antibody

Suggested positive control: recombinant protein.

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.

Specifications

• Antigen: Anthrax Lethal Factor
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Alias: Anthrax LF
• Host Species: Rabbit
• Immunogen: Synthetic peptides corresponding to amino acids 47-65 of the Anthrax LF protein (approx. 90 kD).
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov