12L HETE, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA131514

Catalog No. PIPA131514

Description

12-Hydroxyeicosatetraenoic acid, a metabolite of arachidonic acid, is a highly selective ligand used to label mu-opiod receptors in membranes and tissues. 5-Lipoxygenase (LO)-derived leukotrienes are involved in inflammatory glomerular injury. LO product 12-HETE is associated with pathogenesis of hypertension, and may mediate angiotensin II and TGF beta induced mesengial cell abnormality in diabetic nephropathy. 12-HETE is markedly elevated in the psoriatic lesions and acts as a vasoconstrictor that contributes to high blood pressure in (renovascular) hypertension and pregnancy-induced hypertension. A significant percentage of patients suffering from a selective increase in plasma LDL cholesterol (type IIa hyperlipoproteinaemia) exhibits increased platelet reactivity. This includes enhanced platelet responsiveness against a variety of platelet-stimulating agents ex vivo and enhanced arachidonic acid metabolism associated with increased generation of arachidonic acid metabolites such as 12-HETE, and secretion of platelet-storage products. The 12-s-HETE analog has been reported to augment tumour cell metastatic potential through activation of protein kinase c. 12-HETE can be formed either in the 12-S or 12-R configuration. It has a diversity of biological actions and is generated by a number of tissues including the renal glomerulus and the vasculature. 12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. 12-HETE is a neuromodulator that is synthesized during ischemia. Its neuronal effects include attenuation of calcium influx and glutamate release as well as inhibition of AMPA receptor (AMPA-R) activation. [National Center for Biotechnology Information. PubChem Compound Database; CID=5312983] PA1-31514 detects 12L HETE from human samples.PA1-31514 has been successfully used in radioimmune assay applications.The PA1-31514 immunogen is: Pure 12(L)-HETE conjugated to human serum albumin

Specifications

• Antigen: 12L HETE
• Classification: Polyclonal
• Gene Alias: 12-HETE, 12-Hydroxyeicosatetraenoic acid, 12(L)-Hydroxeicosantetraenoic Acid, 12(L)-HETE
• Immunogen: Pure 12(L)-HETE conjugated to human serum albumin
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Radioimmune Assays (RIA)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at -20°C, Avoid Freeze/Thaw Cycles
• Form: Serum