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12L HETE, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA131514

Catalog No. PIPA131514

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

12-Hydroxyeicosatetraenoic acid, a metabolite of arachidonic acid, is a highly selective ligand used to label mu-opiod receptors in membranes and tissues. 5-Lipoxygenase (LO)-derived leukotrienes are involved in inflammatory glomerular injury. LO product 12-HETE is associated with pathogenesis of hypertension, and may mediate angiotensin II and TGF beta induced mesengial cell abnormality in diabetic nephropathy. 12-HETE is markedly elevated in the psoriatic lesions and acts as a vasoconstrictor that contributes to high blood pressure in (renovascular) hypertension and pregnancy-induced hypertension. A significant percentage of patients suffering from a selective increase in plasma LDL cholesterol (type IIa hyperlipoproteinaemia) exhibits increased platelet reactivity. This includes enhanced platelet responsiveness against a variety of platelet-stimulating agents ex vivo and enhanced arachidonic acid metabolism associated with increased generation of arachidonic acid metabolites such as 12-HETE, and secretion of platelet-storage products. The 12-s-HETE analog has been reported to augment tumour cell metastatic potential through activation of protein kinase c. 12-HETE can be formed either in the 12-S or 12-R configuration. It has a diversity of biological actions and is generated by a number of tissues including the renal glomerulus and the vasculature. 12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. 12-HETE is a neuromodulator that is synthesized during ischemia. Its neuronal effects include attenuation of calcium influx and glutamate release as well as inhibition of AMPA receptor (AMPA-R) activation. [National Center for Biotechnology Information. PubChem Compound Database; CID=5312983] PA1-31514 detects 12L HETE from human samples.PA1-31514 has been successfully used in radioimmune assay applications.The PA1-31514 immunogen is: Pure 12(L)-HETE conjugated to human serum albumin
TRUSTED_SUSTAINABILITY
Specifications

Specifications

12L HETE
Polyclonal
12-HETE, 12-Hydroxyeicosatetraenoic acid, 12(L)-Hydroxeicosantetraenoic Acid, 12(L)-HETE
Pure 12(L)-HETE conjugated to human serum albumin
RUO
Human
Antibody
IgG
ELISA, Radioimmune Assays (RIA)
Unconjugated
Rabbit
100 μL
Primary
Store at -20°C, Avoid Freeze/Thaw Cycles
Serum
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