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  6. 14-3-3 Mouse, Unlabeled, Clone: 12/14-3-3, BD

14-3-3 Mouse, Unlabeled, Clone: 12/14-3-3, BD

Catalog No. BDB561465 Shop All BD Biosciences Products
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BDB561465 50 μg
BDB561466 150 μg
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Catalog No. BDB561465 Supplier BD Biosciences Supplier No. 561465

Description

Mouse Monoclonal Antibody

The family of 14-3-3 proteins has been implicated in numerous cellular processes such as neurotransmission, phospholipase activity, and calcium signaling. The 14-3-3 protein can associate with several proteins involved in cell proliferation, such as Raf-1, Bcr-Abl, middle T antigen, and CDC25 phosphatase. It appears that 14-3-3 proteins enhance the kinase activity of the Raf proto-oncogene equally as well as Ras, thus, implicating 14-3-3 proteins in the Raf/Ras/Map kinase signaling pathway. However, in spite of 14-3-3 direct association with the CDC25 phosphatase, this interaction does not increase the phosphatase activity. It has been reported that this antibody detects 14-3-3 subunits β, γ, η, Θ, and ζ , but not ε nor σ.

TRUSTED_SUSTAINABILITY

Specifications

Antigen 14-3-3
Applications Immunofluorescence, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 12/14-3-3
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human 14-3-3
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Canine, Chicken, Frog, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgM
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For Research Use Only.

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