14-3-3 Mouse, Unlabeled, Clone: 12/14-3-3, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 561466

Catalog No. BDB561466

Description

The family of 14-3-3 proteins has been implicated in numerous cellular processes such as neurotransmission, phospholipase activity, and calcium signaling. The 14-3-3 protein can associate with several proteins involved in cell proliferation, such as Raf-1, Bcr-Abl, middle T antigen, and CDC25 phosphatase. It appears that 14-3-3 proteins enhance the kinase activity of the Raf proto-oncogene equally as well as Ras, thus, implicating 14-3-3 proteins in the Raf/Ras/Map kinase signaling pathway. However, in spite of 14-3-3 direct association with the CDC25 phosphatase, this interaction does not increase the phosphatase activity. It has been reported that this antibody detects 14-3-3 subunits β, γ, η, Θ, and ζ , but not ε nor σ.

Specifications

• Antigen: 14-3-3
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human 14-3-3
• Quantity: 150 μg
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Clone: 12/14-3-3
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
• Isotype: IgM

For Research Use Only.