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MilliporeSigma™ anti-2,2,7-Trimethylguanosine Agarose, Clone: K121,

Catalog No. NA02A05ML Shop All MilliporeSigma Products
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Quantity:
0.5 mL
Conjugate:
Agarose
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Catalog No. Quantity Conjugate
NA02A05ML 0.5 mL Agarose
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Catalog No. NA02A05ML Supplier MilliporeSigma™ Supplier No. NA02A0.5ML

Mouse Monoclonal Antibody

Specifically detects 2,2,7-Trimethylguanosine Clone: K121 in Human, Mouse, Rat samples, and it is validated for Immuno Blotting

The U small nuclear ribonucleoprotein particles (snRNPs) are present in all eukaryotes studied thus far and are involved in the splicing of RNA molecules. snRNPs are composed of several proteins and one or two RNA molecules. The RNA molecules (snRNAs) contain a unique 5' terminal cap structure containing the nucleoside 2,2,7-trimethylguanosine. The 70kDa protein component of U1 snRNP is cleaved during apoptosis, perhaps by a caspase. Monoclonal antibodies to the 5' cap structure react only to snRNAs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 2,2,7-Trimethylguanosine
Applications Immunoblot
Classification Monoclonal
Clone K121
Conjugate Agarose
Formulation In PBS.
Host Species Mouse
Immunogen 2, 7-trimethylguanosine
Quantity 0.5 mL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the exposed 5′ cap structure (2,2,7-trimethylguanosine) of small nuclear RNAs (snRNAs). Also recognizes 7-methylguanosine-capped mRNA.
Target Species Human, Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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