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MilliporeSigma™ anti-2,2,7-Trimethylguanosine Clone: K121,

Catalog No. NA02100UG Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
NA02100UG 100 μg Unconjugated
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Catalog No. NA02100UG Supplier MilliporeSigma™ Supplier No. NA02100UG
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Description

Mouse Monoclonal Antibody

Specifically detects 2,2,7-Trimethylguanosine Clone: K121 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation

The U small nuclear ribonucleoprotein particles (snRNPs) are present in all eukaryotes studied thus far and are involved in the splicing of RNA molecules. snRNPs are composed of several proteins and one or two RNA molecules. The RNA molecules (snRNAs) contain a unique 5' terminal cap structure containing the nucleoside 2,2,7-trimethylguanosine. The 70kDa protein component of U1 snRNP is cleaved during apoptosis, perhaps by a caspase. Monoclonal antibodies to the 5' cap structure react only to snRNAs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 2,2,7-Trimethylguanosine
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Clone K121
Conjugate Unconjugated
Formulation In 0.05M sodium phosphate buffer, 0.2% gelatin.
Host Species Mouse
Immunogen 2, 7-trimethylguanosine
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the exposed 5′ cap structure (2,2,7-trimethylguanosine) of small nuclear RNAs (snRNAs).
Target Species Human, Mouse, Rat
Content And Storage 2°C to 8°C
Form Purified
Isotype IgG1
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