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28/PMCA2 Mouse, Unlabeled, Clone: 28, BD

Catalog No. BDB610932 Shop All BD Biosciences Products
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BDB610932 50 μg
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Catalog No. BDB610932 Supplier BD Biosciences Supplier No. 610932

Description

Mouse Monoclonal Antibody

Depolarization of the plasma membrane during neurotransmitter release or muscle excitation/contraction involves increases in intracellular Ca2+. Homeostasis is reestablished through the action of various enzymes, including ion pumps. PMCAs (Plasma Membrane Calcium ATPases) belong to the P-type family of transport ATPases which couple ATP hydrolysis to the export of intracellular Ca2+. They are characterized by large molecular mass, high affinity for Ca2+, and direct regulation by interaction with Ca2+/calmodulin. Four different genes (PMCA 1-4) and independent alternative splice sites combine to generate multiple PMCA isoforms. PMCA 1-4 are highly homologous, but differ substantially in their N-terminal regions. PMCA1 and 4 are ubiquitously expressed and perform housekeeping roles. However, PMCA2 and 3 exhibit tissue-specific expression and perform more specialized functions. Although PMCA2 and 3 are both expressed to some degree in muscle, PMCA2 is primarily found in the cerebellum. There, it accounts for the majority of neural pump protein. Thus, PMCA2 is thought to be the principal ATPase that functions to maintain Ca2+ homeostasis in response to neural excitation.

TRUSTED_SUSTAINABILITY

Specifications

Antigen 28/PMCA2
Applications Western Blot
Classification Monoclonal
Clone 28
Concentration 250μg/mL
Conjugate Unconjugated
Description Plasma Membrane Calcium ATPases
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Rat PMCA2 aa. 81-193
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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