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4-1BB Ligand Rat anti-Mouse, Unlabeled, Clone: TKS-1, BD

Catalog No. BDB550532 Shop All BD Biosciences Products
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BDB550532 0.5 mg
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Catalog No. BDB550532 Supplier BD Biosciences Supplier No. 550532

Description

Rat Monoclonal Antibody

The TKS-1 antibody reacts with 4-1BB Ligand (4-1BBL), a 97kDa member of the NGF/TNF superfamily which is present on antigen-presenting cells and activated B lymphocytes. 4-1BBL interacts with 4-1BB (CDw137), found predominantly on activated T lymphocytes. This ligand-receptor pair is grouped with pairs such as CD27/CD70, CD30/CD153, OX-40/OX-40L, CD80/CD28, and CD86/CD28, which costimulate T-cell proliferation and cytokine production. The interaction of 4-1BB with 4-1BBL may be reciprocally costimulatory in that 4-1BBL may deliver proliferative signals to B lymphocytes activated by anti-IgM. The TKS-1 mAb stains B cells activated for three days with anti-IgM polyclonal antibody, consistent with an earlier report that soluble 4-1BB-alkaline phosphatase fusion protein binds to anti-IgM-activated B cells. Furthermore, 4-1BBL mRNA has been detected in activated T lymphocytes and activated macrophages. The TKS-1 mAb has been reported to inhibit the binding of soluble 4-1BB to 4-1BBL transfectants and block the in vitro costimulation of T-lymphocyte proliferation by 4-1BBL transfectants.

TRUSTED_SUSTAINABILITY

Specifications

Antigen 4-1BB Ligand
Applications Flow Cytometry
Classification Monoclonal
Clone TKS-1
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen BALB/c mouse B lymphoma line 2PK-3
Purification Method Affinity Purified
Quantity 0.5 mg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C
Isotype IgG2a κ
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For Research Use Only.

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