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4EBP1 (pT69) Mouse anti-Human, Alexa Fluor 647, Clone: M34-273, BD

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BDB560289 50 Tests
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Catalog No. BDB560289 Supplier BD Biosciences Supplier No. 560289

Description

Mouse Monoclonal Antibody

The eukaryotic translation initiation factor 4E-Binding Protein 1 (4EBP1) is a phosphorylated heat- and acid-stable protein (PHAS-I or PHAS-1), and it is regulated by insulin. It is a member of the eIF4E-Binding Protein Family, which also includes the proteins 4EBP2 and 4EBP3. 4EBP1 binds with eukaryotic translation Initiation Factor 4E (eIF4E), which prevents its assembly into the eIF4E complex and inhibits cap-dependent translation. When 4EBP1 is phosphorylated, this binding is disrupted, allowing cap-dependent translation to be activated. Phosphorylation of 4EBP1 is required for protein synthesis, and it mediates the regulation of protein translation by stimuli that signal through the phosphoinositide 3 (PI3) kinase pathway. We found that threonine 69 (T69) is phosphorylated in resting human peripheral blood monocytes, but it is almost undetectable in resting lymphocytes. PI3 kinase inhibitors, such as LY294002 down-regulate the phosphorylation level of 4EBP1 (pT69) in monocytes.

The M34-273 monoclonal antibody recognizes the phosphorylated T69 of activated human 4EBP1.

TRUSTED_SUSTAINABILITY

Specifications

Antigen 4EBP1 (pT69)
Applications Flow Cytometry
Classification Monoclonal
Clone M34-273
Conjugate Alexa Fluor 647
Description 4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Phosphorylated Human 4EBP1 (pT69) Peptide
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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