Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

4F2 hc/CD98HC Mouse anti-Rat, Unlabeled, Clone: 30, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611516

Catalog No. BDB611516

Add to cart



4F2 antigen (CD98) was identified as a heterodimer consisting of an 80 kDa type II glycosylated integral membrane protein 4F2 heavy chain (4F2 hc) linked by disulfide bonds to a hydrophobic, non-glycosylated, 37 kDa protein 4F2 light chain (4F2 lc). The 4F2 hc colocalizes with cadherins at cell adhesion sites and is required for the intracellular targeting of 4F2 heterodimers. 4F2 hc also associates with β1 integrins and overexpression of 4F2 reverses the suppression of β1 integrin activation caused by overexpression of β1 cytoplasmic domains. 4F2 has also been identified as a fusion regulatory protein FRP-1, since anti-FRP-1 antibodies can induce HIV-mediated cell fusion via an integrin system. 4F2 heterodimers are also important for activation of amino acid transport. 4F2 hc is 30% homologous with the amino acid transport activator D2/rBAT and expression of 4F2 hc in Xenopus oocytes induces system y+L amino acid transport. Thus, 4F2 hc may participate in intracellular trafficking and activation of amino acid transporters, as well as in the regulation of integrin signaling.



4F2 hc/CD98HC
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
Western Blot
4F2 hc
Affinity Purified
Rat 4F2 hc aa. 9-204
Cell Biology
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit