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53BP1 Rabbit anti-Fish, Goat, Human, Mouse, Non-human primate, Rat, Biotin, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522752

Catalog No. PIPA522752


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Description

Description

Human has been tested in WB, IHC-P and ICC/IF, mouse and goat have only been tested in ICC/IF. Suggested positive control: U205, 293T, MO59K cell lysates and MEF lysates .

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
Specifications

Specifications

53BP1
Polyclonal
Biotin
TP53BP1
Liquid
TP53BP1, Trp53bp1
The epitope recognized by this antibody maps to a region between residues 350 and 400 of human tumor protein p53 binding protein 1 using the numbering given in entry NP_005648.1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Fish, Goat, Human, Mouse, Non-human primate, Rat
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with no preservative
Q12888, P70399
53BP1, p202, p53-binding protein 1, p53BP1, tumor protein 53-binding protein, 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
Rabbit
IgG
100 μL
4° C, store in dark
Primary
102182833, 27223, 296099, 7158
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