Invitrogen™ 53BP1 Polyclonal Antibody, DyLight™ 488

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522759

Catalog No. PIPA522759

Description

Human samples have been tested in Western Blot and ICC/IF, and mouse samples have been tested in ICC/IF only. Suggested positive control: U205, 293T, and MO59K cell lysates and MEF lysates. Predicted cross-reactivity based on sequence identity: Chimpazee/Equine/Feline/Gibbon/Gorilla/Hamster/Marmoset/Orangutan/Panda/Porcine/Rabbit/Sheep (100%).

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: 53BP1
• Classification: Polyclonal
• Conjugate: DyLight 488
• Gene: TP53BP1
• Gene Alias: 53BP1; FLJ41424; m53BP1; MGC138366; murine p53-binding protein; p202; p53-binding protein 1; p53BP1; TDRD30; TP53; TP53-binding protein 1; Tp53bp1; transformation related protein 53 binding protein 1; transformation related protein 53 binding-protein 1; Trp53bp1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27223, 296099, 478274, 509111, 7158
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: ChIP Assay, Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: 50mM sodium borate with 0.05% sodium azide
• Gene Accession No.: P70399, Q12888
• Gene Symbols: TP53BP1, Trp53bp1
• Immunogen: Region between residues 1925 and the C-terminus (residue 1972) of human 53BP1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Bovine, Rodent, Bat
• Product Type: Antibody
• Isotype: IgG