A2B5 Mouse, Alexa Fluor 647, Clone: 105/A2B5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 563776
The 105/A2B5 monoclonal antibody binds to gangliosides in neural tissue in the retina, brain, spinal cord, and dorsal root ganglia. The antigenic gangliosides are found on the plasma membrane of neural cell bodies, but not axons or dendrites. Expression levels of the gangliosides that mAb 105/A2B5 binds to, including GT3 and its O-acetylated derivative, decrease during embryonic development of the brain. Thus, mAb 105/A2B5 may be used to monitor the maturation of brain tissue. A2B5 antigens have also been associated with numerous tumors, including glioblastoma multiforme tumor cells, pancreatic islet tumor cells, and rat insulinoma cells, and are thought to contribute to chemoresistance and increased tumor proliferation and recurrence.
|Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.|
|Chicken, Human, Murine, Rat|
|Alexa Fluor 647|
|Chicken embryo retina Cells|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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