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A2B5 Mouse, Unlabeled, Clone: 105/A2B5, BD

Catalog No. BDB563775 Shop All BD Biosciences Products
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BDB563775 0.1 mg
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Catalog No. BDB563775 Supplier BD Biosciences Supplier No. 563775

Description

Mouse Monoclonal Antibody

The 105/A2B5 monoclonal antibody binds to gangliosides in neural tissue in the retina, brain, spinal cord, and dorsal root ganglia. The antigenic gangliosides are found on the plasma membrane of neural cell bodies, but not axons or dendrites. Expression levels of the gangliosides that mAb 105/A2B5 binds to, including GT3 and its O-acetylated derivative, decrease during embryonic development of the brain. Thus, mAb 105/A2B5 may be used to monitor the maturation of brain tissue. A2B5 antigens have also been associated with numerous tumors, including glioblastoma multiforme tumor cells, pancreatic islet tumor cells, and rat insulinoma cells, and are thought to contribute to chemoresistance and increased tumor proliferation and recurrence.

TRUSTED_SUSTAINABILITY

Specifications

Antigen A2B5
Applications Flow Cytometry
Classification Monoclonal
Clone 105/A2B5
Concentration 0.5mg/mL
Conjugate Unconjugated
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Mouse
Immunogen Chicken embryo retina Cells
Purification Method Affinity Purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at 4°C
Isotype IgM
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