ABCA1 Rabbit anti-Hamster, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA132129
PA1-32129 detects ABCA1 from rat, hamster, mouse, and human samples. PA1-32129 has been successfully used in immunocytochemistry, immunofluorescence, Western blot, immunohistochemistry (paraffin tissue), and immunoprecipitation applications. The PA1-32129 immunogen is a synthetic peptide: corresponding to amino acids 1100-1300 of Human ABCA 1. Immunogen sequence information is commercially sensitive and details are not available. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
|synthetic peptide corresponding to amino acids 1100-1300 of Human ABCA 1.|
|Antigen Affinity Chromatography|
|Hamster, Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|PBS with 0.05% sodium azide; pH 7-8|
|ABC 1 antibody, ABC Transporter 1 antibody, ABC1 antibody, ATP-binding Cassette 1 antibody, ATP-binding Cassette Transporter 1 antibody, CERP antibody|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|100761226, 11303, 19, 313210|
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