ABCC2, Mouse, Clone: 1C5, Abnova
Mouse monoclonal antibody raised against a partial recombinant ABCC2.
Manufacturer: Abnova Corporation H00001244M01
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeqSequence: LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKA
|ATP-binding cassette, subfamily C (CFTR/MRP), member 2|
|ABCC2 (NP_000383, 214 a.a. ∽314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26kDa.|
|Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|ELISA,Sandwich ELISA,Western Blot|
|In 1X PBS, pH 7.4|
|ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP|
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