ABP-280 Mouse anti-Human, Unlabeled, Clone: 5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610798
ABP-280, also known as non-muscle Filamin, is a homodimeric actin-binding protein often found with membrane glycoproteins where it plays a role in cell motility. The human ABP-280 gene, mapped at the chromosomal region Xq28, consists of 47 exons extending approximately 26kb. The protein has an actin-binding domain at its NH2-terminal region, a central rod-like domain, and a C-terminal domain responsible for the dimerization properties of ABP-280. ABP-280 is ubiquitously expressed and appears also to interact with the β2-integrin subunit of CD18 in leukocytes. Furthermore, the active SEK-1, an immediate activator of stress-activated protein kinases, interacts with ABP-280. Interestingly, cells with an interaction-deficient ABP-280 failed to respond to the TNFα-dependent SEK-1 activation. Thus, ABP-280 is an important regulator of the stress-activated protein kinase signaling pathway.
Immunofluorescence, Immunoprecipitation, Western Blotting
|Immunofluorescence, Western Blot|
|Human ABP-280 aa. 2492-2647|
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