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ABP-280 Mouse anti-Human, Unlabeled, Clone: 5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610798

Catalog No. BDB610798

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

ABP-280, also known as non-muscle Filamin, is a homodimeric actin-binding protein often found with membrane glycoproteins where it plays a role in cell motility. The human ABP-280 gene, mapped at the chromosomal region Xq28, consists of 47 exons extending approximately 26kb. The protein has an actin-binding domain at its NH2-terminal region, a central rod-like domain, and a C-terminal domain responsible for the dimerization properties of ABP-280. ABP-280 is ubiquitously expressed and appears also to interact with the β2-integrin subunit of CD18 in leukocytes. Furthermore, the active SEK-1, an immediate activator of stress-activated protein kinases, interacts with ABP-280. Interestingly, cells with an interaction-deficient ABP-280 failed to respond to the TNFα-dependent SEK-1 activation. Thus, ABP-280 is an important regulator of the stress-activated protein kinase signaling pathway.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

Specifications

ABP-280
5
Unconjugated
Murine
IgG1
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human ABP-280 aa. 2492-2647
50μg
Cell Biology
Monoclonal
Documents
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