Acetyl-CBP/p300 (Lys1499, Lys1535) Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA516185
It is not recommended to aliquot this antibody.This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
|Acetyl-CBP/p300 (Lys1499, Lys1535)|
|0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Q09472, Q92793, B2RWS6, P45481, Q6JHU9|
|Crebbp, Ep300, CBP, RSTS, KAT3A, CREBBP|
|12914, 1387, 170915, 2033, 328572, 54244|
|ChIP assay, Immunoprecipitation, Western Blot|
|Synthetic acetylated peptide corresponding to residues surrounding Lys1535 of human CBP|
|Antigen affinity chromatography|
|Human, Mouse, Non-human primate, Rat|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok