Adaptin β Mouse, Unlabeled, Clone: 74, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB610382	BD Biosciences 610382	150 μg
BDB610381	BD Biosciences 610381	50 μg

Description

Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (γ, α,δ or ε and β1, β2, β3, or β4, respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3, or μ4) and one small chain (σ1, σ2, σ3, or σ4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. β Adaptin subunits (β1, β2, β3, β4) lack sequence homology to adaptins α, γ, δ and ε, but all of these subunits share a similar domain structure. Adaptin β1 (also known as Adaptin β′) and β2 (also known as Adaptin β) have 83% amino acid identity and are found in the AP1 and AP2 complexes, respectively.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Adaptin β
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified

• Clone: 74
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
• Immunogen: Human Adaptin β aa. 75-245
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.