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AFAP Mouse, Unlabeled, Clone: 36, BD

Catalog No. BDB610199 Shop All BD Biosciences Products
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150 μg
50 μg
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BDB610199 50 μg
BDB610200 150 μg
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Catalog No. BDB610199 Supplier BD Biosciences Supplier No. 610199

Description

Mouse Monoclonal Antibody

Chicken embryo fibroblasts (CEF) which are transformed by pp60[src] show anincrease in the steady-state levels of tyrosine-phosphorylated proteins. One of these proteins is the Actin Filament-Associated Protein, AFAP110. This protein forms a stable complex with activated pp60[src] via the SH3 and SH2 domains ofthe src protein. However, tyrosine phosphorylation of AFAP requires only the intact src SH3 domain. AFAP is associated with actin stress fibers in normal CE cells, but following transformation by pp60[src], AFAP becomes localized in rosette-like structures known as podosomes. Several sequence motifs within AFAP110 are predicted to bind to SH2 and to SH3 domains. In vitro analysis of AFAP in normal cell extracts demonstrated that it binds less efficiently to Src SH2-containing fusion proteins than does AFAP from src-transformed cell extracts.

TRUSTED_SUSTAINABILITY

Specifications

Antigen AFAP
Applications Immunofluorescence, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 36
Concentration 250μg/mL
Conjugate Unconjugated
Formulation Chicken, Human, Mouse, Rat
Host Species Mouse
Immunogen Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Chicken, Human, Mouse, Rat
Isotype IgG1
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For Research Use Only.

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