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MilliporeSigma™ anti-Ago1 Clone: 4B8,

Catalog No. MABE1121MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE1121MI 100 μg Unconjugated
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Catalog No. MABE1121MI Supplier MilliporeSigma™ Supplier No. MABE1121
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Description

Rat Monoclonal Antibody

Specifically detects Ago1 Clone: 4B8 in Human samples, and it is validated for Western Blotting

Protein argonaute-1 (UniProt Q9UL18; also known as Argonaute1, Argonaute RISC catalytic component 1, eIF-2C 1, eIF2C 1, Eukaryotic translation initiation factor 2C 1, hAgo1, Putative RNA-binding protein Q99) is encoded by the AGO1 (also known as EIF2C, EIF2C1) gene (Gene ID 26523) in human. Ago1 belongs to the family of argonaute proteins involved in gene expression by regulating gene transcription and RNA splicing in the nucleus, as well as by regulating posttranscriptional gene silencing mediated by siRNAs and microRNAs in the cytosol. Ago1 is shown to interact with chromatin modifiers, splicing factors, and RNA polymerase II. Ago1 and the related Ago2 are also shown to target Hepatitis C Virus (HCV) RNÁ 5'-untranslated region (5'-UTR) in an miR-122-dependent manner, resulting in viral RNA stability and translation stimulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ago1
Applications Western Blot
Classification Monoclonal
Clone 4B8
Conjugate Unconjugated
Formulation Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q9UL18
Gene Symbols AGO1, EIF2C, EIF2C1
Host Species Rat
Immunogen GST-tagged recombinant human Ago1.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_036331.1
Test Specificity Clone 4B8 sepcifically immunoprecipitated FLAG-tagged Ago1,but not FLAG-tagged Ago2, Ago3, or Ago4 (Ender, C., et al. (2008). Mol. Cell. 32(4):519-528).
Target Species Human
Content And Storage 2°C to 8°C for one year from date of shipment
Form Purified
Isotype IgG2a κ
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For Research Use Only

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