AIP Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1514
PA1-514 detects aryl hydrocarbon receptor interacting protein (AIP) from mouse samples. PA1-514 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing AIP from Hepa 1 SV40 cell lysate, as well as recombit mouse AIP. PA1-514 immunogen is full length, bacterially expressed mouse recombit AIP.Studies have shown that the unactivated aryl hydrocarbon receptor (AhR) exists in a heterotetrameric 9S core with hsp90 and the aryl hydrocarbon receptor interacting protein (AIP, also known as ARA9 or XAP-2). AIP is a 330 amino acid protein that resembles the 52 kDa FKBP52 protein sequence, but does not share the same affinity for the hsp90-glucocorticoid receptor complex. It has been demonstrated through studies that AIP helps stabilize the AIP-hsp90-AhR complex and protects the AhR receptor from ubiquitination under heat stress conditions. These studies also suggest that AIP plays an important role in regulating the rate of AhR turnover by delaying AhR nuclear translocation after ligand binding. Immunopreciatation experiments have also shown that the N-terminus of AIP is required for the stability of the dioxin receptor-hsp90-AIP complex and the C-terminus is needed for direct contact and binding to hsp90.
|Full length, bacterially expressed mouse recombit AIP.|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|AH receptor-interacting protein, Aryl-hydrocarbon receptor-interacting protein, Immunophilin homolog ARA9, HBV-X-associated protein 2|
|-20° C, Avoid Freeze/Thaw Cycles|
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