AKT1, Rabbit, Monoclonal Antibody, Abnova™

Rabbit monoclonal antibody raised against a human AKT1 peptide using ARM Technology.

Supplier:  Abnova Corporation H00000207K

Catalog No. 89-200-268

Includes: Up to three rabbit IgG clones of 1mg each will be delivered to customer.

Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Library Construction: Nonfusion antibody library from rabbit spleen (ARM Technology)
Expression: Overexpression vector and transfection into 293H cell line

Order Info

1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.

Specifications

• Antigen: AKT1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Formulation: In 1X PBS, pH 7.4
• Gene Accession No.: AKT1
• Gene Symbols: AKT1
• Immunogen: A synthetic peptide of human AKT1
• Regulatory Status: RUO
• Gene ID (Entrez): 207
• Content And Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 1mg
• Description: v-akt murine thymoma viral oncogene homolog 1
• Gene: AKT1
• Gene Alias: AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
• Host Species: Rabbit
• Quantity: 1 mg x up to 3 Abs
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid