ACVR1C Mouse anti-Rat, Clone: 118311, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523803
In Western blots, no cross-reactivity with recombit human Activin R1B is observed. Reconstitute at 0.1 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
|PBS with 5% trehalose and No Preservative|
|ACVR1C, Activin receptor-like kinase 7, ACTR-IC, Activin receptor type IC, ACVRLK7, Activin receptor type-1C, ALK7, Activin A receptor, type IC, ALK-7|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Mouse myeloma cell line NS0-derived recombit rat ALK-7 Leu26-Arg108|
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