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ACVR1C Mouse anti-Rat, Clone: 118311, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523803

Catalog No. PIMA523803


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Description

Description

In Western blots, no cross-reactivity with recombit human Activin R1B is observed. Reconstitute at 0.1 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling.
Specifications

Specifications

ACVR1C
Monoclonal
0.1 mg/mL
PBS with 5% trehalose and No Preservative
P70539
ACVR1C, Activin receptor-like kinase 7, ACTR-IC, Activin receptor type IC, ACVRLK7, Activin receptor type-1C, ALK7, Activin A receptor, type IC, ALK-7
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
245921
Flow Cytometry, Western Blot
118311
Unconjugated
Acvr1c
Lyophilized
ACVR1C
Mouse myeloma cell line NS0-derived recombit rat ALK-7 Leu26-Arg108
Protein A/G
RUO
Antibody
Monoclonal
Rat
Documents
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