Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PC32550UL

MilliporeSigma™ anti-alpha-Synuclein (Ab-1) (123-140), Polyclonal

Catalog No. PC32550UL Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
50 μL
Conjugate:
Unconjugated
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity Conjugate
PC32550UL 50 μL Unconjugated
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PC32550UL Supplier MilliporeSigma™ Supplier No. PC32550UL

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Guinea pig Polyclonal Antibody

Specifically detects α-Synuclein (123-140) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immuno Blotting

The major component of the vascular and plaque amyloid deposits in Alzheimer's disease (AD) is the amyloidβ peptide. Non-Aβ component of Alzheimer's disease amyloid (NAC) is the second component in the amyloid plaques from brain tissues of AD patients. Its precursor protein (NACP) is now known to be identical toα-synuclein, a presynaptic protein in the human brain. In AD, synuclein/NAC proteins are found in presynaptic cholinergic nerve terminals that degenerate early in AD and are closely linked toβ amyloid fibrils in senile plaques.α-synuclein is a highly conserved protein that shows 95% homology with rat synuclein 1 and good homology with Torpedo synuclein from the electric organ synapse and bovine phosphoneuroprotein 14 (PNP-14), a brain specific protein present in synapses. Recentlyα-synuclein has been linked to some cases of familial Parkinson's disease (PD), localizing in Lewy bodies, hallmark lesions of degenerating neurons in the brains of patients with PD. A missense mutation in the gene encodingα-synuclein gene has been identified in some of these PD patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen α-Synuclein (123-140)
Applications Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen)
Classification Polyclonal
Conjugate Unconjugated
Formulation Undiluted serum.
Host Species Guinea Pig
Immunogen a synthetic peptide (EAYEMPSEEGYQDYEPEA) corresponding to amino acids 123-140 of the C-terminus of rat, alpha;-synuclein
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes theα-synuclein protein.
Target Species Bovine, Human, Mouse, Rat
Content And Storage −20°C
Form Undiluted
Isotype IgG
Show More Show Less

For Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.