MilliporeSigma anti-alpha-Synuclein (Ab-1) (123-140), Polyclonal
Guinea pig Polyclonal Antibody
Manufacturer: MilliporeSigma PC32550UL
Specifically detects α-Synuclein (123-140) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunohistochemistry (Frozen), Immuno BlottingThe major component of the vascular and plaque amyloid deposits in Alzheimer's disease (AD) is the amyloidβ peptide. Non-Aβ component of Alzheimer's disease amyloid (NAC) is the second component in the amyloid plaques from brain tissues of AD patients. Its precursor protein (NACP) is now known to be identical toα-synuclein, a presynaptic protein in the human brain. In AD, synuclein/NAC proteins are found in presynaptic cholinergic nerve terminals that degenerate early in AD and are closely linked toβ amyloid fibrils in senile plaques.α-synuclein is a highly conserved protein that shows 95% homology with rat synuclein 1 and good homology with Torpedo synuclein from the electric organ synapse and bovine phosphoneuroprotein 14 (PNP-14), a brain specific protein present in synapses. Recentlyα-synuclein has been linked to some cases of familial Parkinson's disease (PD), localizing in Lewy bodies, hallmark lesions of degenerating neurons in the brains of patients with PD. A missense mutation in the gene encodingα-synuclein gene has been identified in some of these PD patients.
|a synthetic peptide (EAYEMPSEEGYQDYEPEA) corresponding to amino acids 123-140 of the C-terminus of rat, alpha;-synuclein|
|Bovine, Human, Murine, Rat|
|Immuno Blotting, Immunoblot, Immunofluorescence, Immunohistochemistry (Frozen)|
|Recognizes theα-synuclein protein.|
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