Invitrogen™ AMER1 Monoclonal Antibody (729419)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524343

Catalog No. PIMA524343

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

The AMER1 gene encodes the protein APC membrane recruitment 1, also known as Wilms tumor 1-associating protein (WT1-associating protein). This protein plays a significant role in the Wnt signaling pathway, which is critical for cellular processes such as proliferation, differentiation, and migration. AMER1 interacts with the adenomatous polyposis coli (APC) protein and is involved in the regulation of β-catenin, a key mediator of Wnt signaling. By recruiting APC to the cell membrane, AMER1 facilitates the degradation of β-catenin, thereby acting as a negative regulator of the pathway. This function is vital in maintaining cellular homeostasis and preventing uncontrolled cell growth. Mutations or dysregulation of AMER1 are associated with various cancers, including colorectal cancer, as aberrant Wnt signaling can lead to oncogenesis. Moreover, germline mutations in AMER1 are linked to conditions such as osteoporosis-pseudoglioma syndrome, highlighting its role in bone development and eye health. Ongoing research focuses on elucidating the detailed mechanisms of AMER1's involvement in signaling pathways and its potential as a therapeutic target in cancer and genetic disorders.

Specifications

• Antigen: AMER1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q5JTC6
• Gene Symbols: AMER1
• Immunogen: E. coli-derived recombinant human WTX Met421-Leu573.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot, Immunocytochemistry
• Clone: 729419
• Conjugate: Unconjugated
• Gene: AMER1
• Gene Alias: 2810002O09Rik; adenomatous polyposis coli membrane recruitment 1; Amer1; APC membrane recruitment 1; APC membrane recruitment protein 1; AW492303; Fam123b; family with sequence similarity 123, member B; family with sequence similarity 123B; OSCS; protein Fam123b; RGD1560322; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 139285
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized