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Aminoacylase Rat anti-Human, Clone: 475626, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524193

Catalog No. PIMA524193



Description

Description

This antibody detects recombit human Aminoacylase/ACY1 in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombit mouse ACY1 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.
Specifications

Specifications

Aminoacylase
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q03154
ACY-1, ACY1D, N-acyl-L-amino-acid amidohydrolase, acylase, aminoacylase-1
Rat
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
95
Immunoprecipitation, Western Blot
475626
Unconjugated
ACY1
Lyophilized
ACY1
Sf 21-derived recombit human Aminoacylase/ACY1 Thr2-Ser408
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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