Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PC287100UG

MilliporeSigma™ anti-AML3, Polyclonal

Catalog No. PC287100UG Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
100 μg
Conjugate:
Unconjugated
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity Conjugate
PC287100UG 100 μg Unconjugated
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PC287100UG Supplier MilliporeSigma™ Supplier No. PC287100UG

Description

Rabbit Polyclonal Antibody

Specifically detects AML3 Clone: in Human, Mouse, Rat samples, and it is validated for Gel Supershift, Immuno Blotting

The family of nuclear transcription factors represented by AML are important transactivators of tissue-specific genes of hematopoietic and bone cell lineage. There are currently three mammalian proteins that are members of this family, AML1, AML2, and AML3. The AML proteins in turn form heterodimers with another protein, CBFβ and it is this complex that produces the transcription factor activity. Within this complex the AML protein provides the DNA binding function. The AML gene was discovered in 1991 by cloning the t(8;21) translocation that is common to AML. Structurally the AML protein contains a transactivation domain at the C-terminus is homologous with theDrosophila runt gene that acts as the DNA binding area of the protein. AML3, the third member of the AML family, is unique from the other family members in that it also possesses osteoblast-specific transcriptional regulation properties. AML3 has been demonstrated as a single transcript of 5.4 kb in bone tissues where the protein encoded by the gene has been shown to be present in the osteoblast-specific promoter binding complex. Like other AML proteins, AML3 contains the runt domain, a putative ATP binding site, and a proline and serine rich C-terminal half. AML3 is also the predominant runt domain containing transcription factor in Buffalo Rat liver cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AML3
Applications Gel Supershift, Immunoblot, Immunoblot
Classification Polyclonal
Conjugate Unconjugated
Formulation In PBS.
Host Species Rabbit
Immunogen a synthetic peptide [(K)TDVPRRISDDDTATSD] corresponding to amino acids 319-334 from human AML3
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes the ∽65kDa, the ∽60kDa, and the ∽45kDa AML3 proteins in transfected COS or BRL (buffalo rat liver) cells.
Target Species Human, Mouse, Rat
Content And Storage −20°C
Form Purified
Isotype IgG
Show More Show Less

For Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.