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APC5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524454

Catalog No. PIPA524454

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
Specifications

Specifications

APC5
Polyclonal
PBS with 0.09% sodium azide
Q9UJX4
APC5, anaphase-promoting complex subunit 5, cyclosome subunit 5
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
51433
Flow Cytometry, Western Blot
Unconjugated
ANAPC5
Liquid
ANAPC5
KLH conjugated synthetic peptide between 156-185 amino acids from the central region of human ANAPC5
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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