MilliporeSigma™ anti-Angiopoietin-1, N-terminus (Ang-1); Polyclonal; ™ (Chemicon™)

Supplier:  MilliporeSigma™ AB3120/DEL

Catalog No. 50-173-430

Description

The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 (mouse and human Ang-1; 498aa with 98% identity) is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic dvevelopment, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 (mouse and human Ang-2, 496aa with 85% identity) may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ∽60% sequence homology.

ELISA, Western Blotting

Specifications

• Antigen: Angiopoietin-1, N-terminus (Ang-1)
• Conjugate: Unconjugated
• Immunogen: 20 amino acid peptide sHuence near the amino-terminus of mouse Ang-1.
• Quantity: 50 μg
• Research Discipline: Cell Structure
• Target Species: Mouse

• Classification: Polyclonal
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary