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Annexin II Mouse, Unlabeled, Clone: 5, BD

Catalog No. BDB610068 Shop All BD Biosciences Products
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Catalog No. BDB610068 Supplier BD Biosciences Supplier No. 610068
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Description

Mouse Monoclonal Antibody

Annexin II (p36), originally discovered as a substrate for the src oncogene, is one of the most studied members of the annexin family of calcium-dependent phospholipid-binding proteins. It exists in cells as either a monomer or a heterotetramer complexed with p11, an S100-related protein. In vitro, it has been found that unphosphorylated annexin II is capable of causing aggregation of chromaffin granules, and, upon phosphorylation, induces fusion of the granules membranes. A similiar phenomenon may occur in the final steps of exocytosis after cytoplasmic annexin translocates to the subplasmalemmal region and is phosphorylated by protein kinase C. However, other studies refute annexin II's involvement in exocytosis, and a conclusive role for annexin II in membrane trafficking remains debated.

Host Species: Mouse
Clone: 5
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Annexin II aa. 123-328
Formula Weight [Chemical]: 36kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

TRUSTED_SUSTAINABILITY

Specifications

Antigen Annexin II
Applications Western Blot
Classification Monoclonal
Clone 5
Concentration 250μg/mL
Conjugate Unconjugated
Description Lipocortin II, Calpactin I
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Annexin II aa. 123-328
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Research Discipline Cell Biology
Primary or Secondary Primary
Target Species Canine, Chicken, Human, Mouse, Rat
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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